The DAQ 2000 series of PC based data acquisition boards perform simultaneous sampling on 4 channels in differential input configuration. They also provide two analog output channels with waveform generation capability, which can be performed simultaneously with the analog inputs.
The DAQ 2000 series data acquisition boards incorporate a custom instrumentation amplifier to settle the signal before going into one of the 4 A/D converters for high-gain, fast sampling applications. The DAQ 2000 series uses auto-calibration to adjust offset and gain errors of the analog input and output channels, so you don't need to adjust potentiometers to calibrate the boards.
